BioNodulo Documentation
Welcome to the BioNodulo documentation. BioNodulo is a node-based workflow platform for bioinformatics — visually build and execute computational biology pipelines by connecting nodes that represent bioinformatics tools.
Quick Links
Getting Started
Install BioNodulo and run your first workflow in under 10 minutes.
Cloud Platform
Run workflows at scale on our cloud infrastructure.
Node Reference
Browse all available bioinformatics nodes and their parameters.
What is BioNodulo?
BioNodulo provides a visual, drag-and-drop interface where researchers construct computational pipelines by connecting nodes representing bioinformatics tools (BWA, GATK, FastQC, Cell Ranger, and more). Workflows execute on cloud infrastructure optimized for RAM-intensive, long-running genomic analyses.
If you have ever used ComfyUI for image generation, the model will feel familiar: BioNodulo is “ComfyUI for bioinformatics.” Instead of wiring together diffusion samplers and VAEs, you wire together aligners, variant callers, and quality-control tools — and instead of running for seconds on a GPU, your graphs can run for hours or days on large-memory CPU instances.
Open Core Model
- Desktop Application — Free, open-source (GPL-3), runs locally on your own machine. The full node editor and execution engine, no account required.
- Cloud Platform — Scalable compute, team collaboration, AI features, and credit-based execution billing. Editing is always free; you only pay when you run.
- Node Registry — Community-contributed bioinformatics nodes, packaged and versioned so workflows stay reproducible.
Why node-based?
- Reproducibility. A workflow is a JSON document. Share it, version it, and re-run it months later with identical results.
- Transparency. Every parameter of every tool is visible on the canvas — no hidden shell scripts.
- Composability. Connect the output of one tool to the input of another by dragging an edge; the platform validates that the data types are compatible.
- Scale on demand. Run a small test locally on your desktop, then execute the same graph against a 256 GB cloud instance without changing a thing.
Choose your path
| You want to… | Start here |
|---|---|
| Understand the product | Introduction |
| Run locally, no account | Desktop Installation |
| Run in the cloud in minutes | Cloud Quickstart |
| Build your first pipeline | Your First Workflow |
| Learn how nodes, edges and runs work | Core Concepts |
| Look up a specific tool | Node Reference |
| Integrate via the API | API Reference |
| Contribute a node | Creating Custom Nodes |
Getting Help
- Discord Community — real-time chat
- GitHub Issues — bug reports
- GitHub Discussions — questions